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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MKI67 All Species: 6.06
Human Site: S1618 Identified Species: 19.05
UniProt: P46013 Number Species: 7
    Phosphosite Substitution
    Charge Score: -0.14
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P46013 NP_001139438.1 3256 358694 S1618 A K V A C K S S Q P D P D K N
Chimpanzee Pan troglodytes XP_508147 3257 358658 S1619 A K V A C K S S Q P D P D K N
Rhesus Macaque Macaca mulatta XP_001089669 2126 233775 P624 G R K S G N L P S K R A S I S
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus NP_001074586 3177 350846 P1588 S T M L A R S P Q L G P V R T
Rat Rattus norvegicus XP_225460 3119 343332 V1238 A K V S L E S V Q P Q L V I T
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_421822 2556 283606 K1054 S V S V N P E K Q V S Q V R S
Frog Xenopus laevis NP_001128553 2510 270869 T1008 V D V S L M Q T P E E L G E M
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_782273 1825 188999 P323 P T P K K A S P A P A K K A S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 97.9 55.1 N.A. N.A. 43.1 43.1 N.A. N.A. 22.4 21.7 N.A. N.A. N.A. N.A. N.A. 24.1
Protein Similarity: 100 98.7 57.3 N.A. N.A. 58.2 57 N.A. N.A. 38.5 38.1 N.A. N.A. N.A. N.A. N.A. 34.9
P-Site Identity: 100 100 0 N.A. N.A. 20 40 N.A. N.A. 6.6 6.6 N.A. N.A. N.A. N.A. N.A. 13.3
P-Site Similarity: 100 100 20 N.A. N.A. 46.6 53.3 N.A. N.A. 26.6 33.3 N.A. N.A. N.A. N.A. N.A. 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 38 0 0 25 13 13 0 0 13 0 13 13 0 13 0 % A
% Cys: 0 0 0 0 25 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 13 0 0 0 0 0 0 0 0 25 0 25 0 0 % D
% Glu: 0 0 0 0 0 13 13 0 0 13 13 0 0 13 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 13 0 0 0 13 0 0 0 0 0 13 0 13 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 25 0 % I
% Lys: 0 38 13 13 13 25 0 13 0 13 0 13 13 25 0 % K
% Leu: 0 0 0 13 25 0 13 0 0 13 0 25 0 0 0 % L
% Met: 0 0 13 0 0 13 0 0 0 0 0 0 0 0 13 % M
% Asn: 0 0 0 0 13 13 0 0 0 0 0 0 0 0 25 % N
% Pro: 13 0 13 0 0 13 0 38 13 50 0 38 0 0 0 % P
% Gln: 0 0 0 0 0 0 13 0 63 0 13 13 0 0 0 % Q
% Arg: 0 13 0 0 0 13 0 0 0 0 13 0 0 25 0 % R
% Ser: 25 0 13 38 0 0 63 25 13 0 13 0 13 0 38 % S
% Thr: 0 25 0 0 0 0 0 13 0 0 0 0 0 0 25 % T
% Val: 13 13 50 13 0 0 0 13 0 13 0 0 38 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _